| Expression pattern: |
UP |
| Associated gene: |
SRSF1 |
| Associated microRNA: |
miR-34b-5p |
| Biological function: |
Promotes gefitinib resistance (increased IC50), promotes proliferation/colony formation, and inhibits apoptosis in gefitinib-resistant NSCLC cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-34b-5p, thereby upregulating SRSF1 and enhancing gefitinib resistance and malignant progression. |
| Biological pathway or process: |
chemoresistance (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
circ_0001786 expression was correlated with tumor stage, tumor size, and lymph node metastasis; proposed as a potential target for improving treatment of gefitinib-resistant NSCLC patients. |
| Description: |
circ_0001786 is up-regulated in gefitinib-resistant NSCLC tissues and cells and promotes gefitinib resistance, colony formation, and reduced apoptosis. Mechanistically, it sponges miR-34b-5p to relieve repression of SRSF1, forming a circ_0001786/miR-34b-5p/SRSF1 axis that drives malignant progression and drug tolerance. |
| Confidence score: |
0.6521 |