circRNA basic information
circBase ID: hsa_circ_0101050
Name: hsa_circ_UGGT2
Synonym: circ_0101050 / circ_ 0,101,050
Host Gene: UGGT2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021063
MONDO name: malignant colon neoplasm
Disease details: colon cancer
Disease DO ID:
 219
Disease MeSH ID:
 -
Disease NCIt ID:
 C9242
Disease ICD11 ID:
 1265576634
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; normal tissues
Cell lines:

FHC; HCT116; SW620; SW480
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MELK, Ago2
Associated microRNA: miR-140-3p
Biological function: promotes proliferation and migration; inhibits apoptosis; promotes tumor growth in vivo
Molecular mechanism: acts as a miR-140-3p sponge to regulate MELK (ceRNA mechanism)
Biological pathway or process:

proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

circ_0101050 is up-regulated in colon cancer tissues and cell lines and promotes malignant phenotypes (proliferation, colony formation, migration) while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-140-3p, thereby relieving repression of MELK and enhancing tumor growth in vitro and in a xenograft model.
Confidence score:

0.7009
Other information
Title:

Hsa_circ_0101050 accelerates the progression of Colon cancer by targeting the miR-140-3 p/MELK axis.

Journal: Translational oncology
Published: 2024
PubMed ID: 38579527
Study type:

combined biological and clinical study
Data availability: All of the information produced or analyzed for this work is contained in this article.
Code availability: -