| Expression pattern: |
DS |
| Associated gene: |
TRPS1, FGFR3, 73 mRNAs |
| Associated microRNA: |
hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-99b-5p |
| Biological function: |
Potentially participates in osteosarcoma metastasis and may have prognostic value for OS through correlation with TRPS1 and downstream FGFR3. |
| Molecular mechanism: |
circRNA-based competing endogenous RNA network involving miRNAs and mRNAs; correlation with host gene TRPS1 and downstream target gene FGFR3 |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (other); mTOR signaling pathway (other); stemness (other); drug resistance (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0085360 might have the potential to predict the OS prognosis. |
| Description: |
hsa_circ_0085360 was identified as a metastasis-related osteosarcoma circRNA in a predicted ceRNA network. It showed the strongest correlation with its host gene TRPS1, and its downstream target FGFR3 and TRPS1 were associated with event-free and overall survival, suggesting potential prognostic relevance. |
| Confidence score: |
0.1768 |