circRNA basic information
circBase ID: hsa_circ_0008274
Name: hsa_circ_UGGT2
Synonym: -
Host Gene: UGGT2
Genomic location(hg19): chr13:96485180-96489456:-
Genomic location(hg38): chr13:95832926-95837202:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissues; matched adjacent normal tissues
Cell lines:

A549; CALU-3; SPC-A-1; GLC-82; HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: HMGA2
Associated microRNA: miR-578
Biological function: Inhibits LUAD cell proliferation, invasion and migration.
Molecular mechanism: Acts as a ceRNA by sponging miR-578, thereby regulating HMGA2.
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); migration (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0008274 is down-regulated in LUAD tissues and cell lines. Its overexpression suppresses LUAD cell proliferation, invasion and migration by sponging miR-578 and relieving miR-578-mediated regulation of HMGA2, forming a hsa_circ_0008274/miR-578/HMGA2 ceRNA axis.
Confidence score:

0.779
Other information
Title:

Overexpression of hsa_circ_0008274 inhibited the progression of lung adenocarcinoma by regulating HMGA2 via sponging miR-578.

Journal: Thoracic cancer
Published: 2021
PubMed ID: 34236145
Study type:

combined biological and clinical study
Data availability: -
Code availability: -