| Expression pattern: |
UP |
| Associated gene: |
PI3K/Akt pathway |
| Associated microRNA: |
- |
| Biological function: |
circ_0007503 promotes breast carcinogenesis-associated phenotypes and reduces the anti-cancer effects of eriodictyol; blocking eriodictyol-induced downregulation of circ_0007503 reduces eriodictyol cytotoxicity, apoptosis induction, and PI3K/Akt pathway suppression in breast cancer cells. |
| Molecular mechanism: |
Eriodictyol targets and downregulates circ_0007503, thereby repressing PI3K/Akt signaling; circ_0007503 overexpression counteracts eriodictyol-mediated cytotoxicity and PI3K/Akt pathway suppression. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
circ_0007503 is up-regulated during breast carcinogenesis and is downregulated by eriodictyol in breast cancer cells, carcinogen-transformed MCF10A cells, and rat mammary tumors. Functional rescue by circ_0007503 overexpression reduces eriodictyol-induced cytotoxicity and weakens repression of the PI3K/Akt pathway, suggesting that circ_0007503 supports breast carcinogenesis-associated signaling and modulates eriodictyol response. |
| Confidence score: |
0.4236 |