circRNA basic information
circBase ID: hsa_circ_0002483
Name: hsa_circ_PTK2
Synonym: -
Host Gene: PKT-2
Genomic location(hg19): chr8:141874410-141900868:-
Genomic location(hg38): chr8:140864311-140890769:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005545
MONDO name: staphylococcus aureus infection
Disease details: intracellular Staphylococcus aureus infection
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C122576
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Hfob1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTK2
Associated microRNA: hsa-miR-6886-5p, hsa-miR-6765-5p, hsa-miR-182-5p
Biological function: may negatively regulate epithelial cell signaling upon bacterial invasion
Molecular mechanism: predicted miRNA sponge (ceRNA-like) via binding to hsa-miR-6886-5p
Biological pathway or process:

bacterial invasion of epithelial cells (other); ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0002483 is reported as significantly down-regulated in S. aureus-infected human osteoblasts by RNA-seq. It is predicted to bind miRNAs including hsa-miR-6886-5p and is negatively correlated with PTK2, suggesting a potential inhibitory role in bacterial-invasion-related signaling.
Confidence score:

0.1768
Other information
Title:

Intracellular Staphylococcus aureus infection in human osteoblasts: circRNA expression analysis.

Journal: Heliyon
Published: 2024
PubMed ID: 38560264
Study type:

biological research
Data availability: GSE217234
Code availability: -