| Expression pattern: |
UP |
| Associated gene: |
PTK2 |
| Associated microRNA: |
hsa-miR-6886-5p, hsa-miR-6812-3p, hsa-miR-6769b-5p, hsa-miR-6765-5p, hsa-miR-182-5p |
| Biological function: |
may play a positive regulatory role in epithelial cell signaling upon bacterial invasion |
| Molecular mechanism: |
predicted miRNA sponge (ceRNA-like) via binding to hsa-miR-6886-5p and other miRNAs |
| Biological pathway or process: |
bacterial invasion of epithelial cells (other); ceRNA regulation (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
suggesting that they may serve as reliable biomarkers |
| Description: |
hsa_circ_0085769 is reported as up-regulated in S. aureus-infected human osteoblasts by RNA-seq and is predicted to act as a miRNA-binding circRNA. It is positively correlated with PTK2 and is proposed to influence bacterial-invasion-related signaling via miRNAs such as hsa-miR-6886-5p. |
| Confidence score: |
0.1768 |