circRNA basic information
circBase ID: hsa_circ_0017252
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:243776972-244006584:-
Genomic location(hg38): chr1:243613670-243843282:-
Subcellular localization: cytoplasm; exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal tissue; serum; tumor tissues
Cell lines:

GES-1; MKN-45; MKN45; AGS; SNU-5; THP-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: DUSP2, RUNX3, E-cadherin, N-cadherin, Vimentin, STAT3, p-STAT3, CD206
Associated microRNA: miR-17-5p
Biological function: Overexpression of hsa_circ_0017252 suppresses GC malignancy by inhibiting cell viability, migration, invasion, EMT-like marker changes, tumor growth, and macrophage M2-like polarization, while inducing GC cell apoptosis.
Molecular mechanism: hsa_circ_0017252 acts as a miR-17-5p sponge to upregulate DUSP2, inhibit p-STAT3/STAT3 signaling, and reduce macrophage M2-like polarization; hsa_circ_0017252 can also be transferred from GC cells to macrophages via exosomes.
Biological pathway or process:

ceRNA regulation (other); apoptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); macrophage polarization (inhibits); immune regulation (other); JAK/STAT (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; FISH / smFISH; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Flow Cytometry（Non-apoptosis/cycle）; IF (Immunofluorescence); ELISA; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry)
Clinical significance:

hsa_circ_0017252 was significantly downregulated in GC tissues and serum of patients with GC, suggesting potential relevance to GC diagnosis or treatment development, but no formal diagnostic or prognostic analysis was reported.
Description:

hsa_circ_0017252 is downregulated in GC tissues, serum, and GC cells. It suppresses GC malignancy by sponging miR-17-5p, upregulating DUSP2, reducing p-STAT3 signaling, inhibiting macrophage M2-like polarization, and thereby decreasing GC cell migration, invasion, EMT-like changes, and tumor growth while promoting apoptosis.
Confidence score:

0.7761
Other information
Title:

Exosomal hsa_circ_0017252 attenuates the development of gastric cancer via inhibiting macrophage M2 polarization.

Journal: Human cell
Published: 2022
PubMed ID: 35796939
Study type:

combined biological and clinical study
Data availability: The datasets evaluated here are all available from the corresponding author upon reasonable request; supplementary material available at https:// doi. org/ 10. 1007/ s13577-022-00739-9
Code availability: -