| Expression pattern: |
UP |
| Associated gene: |
FTO, SLC7A5, YTHDF2 |
| Associated microRNA: |
- |
| Biological function: |
promotes gastric cancer cell proliferation and tumor growth; stabilizes SLC7A5 and increases membrane SLC7A5, facilitating leucine uptake and activating mTOR signaling |
| Molecular mechanism: |
FTO removes m6A from circFAM192A to protect it from degradation; m6A reader YTHDF2 recognizes circFAM192A to promote its decay; circFAM192A directly binds SLC7A5 protein and inhibits its degradation, increasing membrane SLC7A5 and activating mTOR signaling |
| Biological pathway or process: |
proliferation (promotes); m6A modification (other); mRNA stability (promotes); mTOR signaling (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Northern Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; MeRIP / MeRIP-seq; Transfection; CCK8; EdU Staining; Colony Formation Assay; Western Blot; IF (Immunofluorescence); ELISA; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circFAM192A is up-regulated in gastric cancer tissues and promotes GC cell proliferation and xenograft tumor growth. Mechanistically, FTO-mediated m6A demethylation stabilizes circFAM192A by reducing YTHDF2-dependent decay; circFAM192A directly binds SLC7A5 protein to inhibit its degradation, increasing membrane SLC7A5, leucine uptake, and mTOR pathway activation. |
| Confidence score: |
0.8855 |