| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-511-5p, hsa-miR-130b-5p, hsa-miR-642a-5p, hsa-miR-532-3p, hsa-miR-329-5p |
| Biological function: |
Potentially involved in colorectal cancer development and tumor progression; lower expression was associated with lymph node metastasis and TNM stage; may serve as a diagnostic biomarker. |
| Molecular mechanism: |
Putative miRNA sponge mechanism based on predicted miRNA binding sites. |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Lower expression was associated with poor prognosis of CRC; AUC for discriminating CRC was 0.699. |
| Description: |
hsa_circRNA_103809 was significantly down-regulated in colorectal cancer tissues and its lower expression was associated with lymph node metastasis and TNM stage. The study suggests that it may serve as a diagnostic biomarker and may function through a putative circRNA-miRNA sponge mechanism. |
| Confidence score: |
0.6556 |