circRNA basic information
circBase ID: hsa_circ_0001175
Name: hsa_circ_YTHDF1
Synonym: circ_0001175 / circYTHDF1
Host Gene: YTHDF1
Genomic location(hg19): chr20:61826924-61827836:-
Genomic location(hg38): chr20:63195572-63196484:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor specimens / primary tumors
Cell lines:

HCCLM3; Huh‐7; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MDM4, P53, p21
Associated microRNA: miR‐130a‐5p
Biological function: promotes proliferation, migration, invasion, and EMT; inhibits P53 pathway activation
Molecular mechanism: NS3-upregulated circ_0001175 acts as a miRNA sponge for miR-130a-5p, increasing MDM4 and suppressing P53/p21 signaling, promoting malignant phenotypes
Biological pathway or process:

p53 signaling (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; BrdU; EdU Staining; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Clinical Sample Validation; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining
Clinical significance:

-
Description:

In HCV-related HCC, NS3 upregulates circ_0001175 (circYTHDF1), which mainly localizes to the cytoplasm and sponges miR-130a-5p. This relieves miR-130a-5p-mediated suppression of MDM4, inhibits P53/p21 signaling, and promotes proliferation, migration, invasion, EMT, tumor growth and metastasis.
Confidence score:

0.8256
Other information
Title:

NS3 of hepatitis C virus drives hepatocellular carcinoma progression through a novel RNA-interference pathway.

Journal: Journal of cell communication and signaling
Published: 2025
PubMed ID: 40226576
Study type:

combined biological and clinical study
Data availability: All data can be provided as needed.
Code availability: -