circRNA basic information
circBase ID: -
Name: -
Synonym: hsa circ 21439
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer liver metastasis tissues; primary breast tumor tissues; liver metastasis tissues
Cell lines:

MDA-MB-231; 231LM
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: EphA2, SOX4
Associated microRNA: miR-26b, miR-335
Biological function: May promote breast cancer liver metastases as an upregulated circRNA and potential miRNA sponge.
Molecular mechanism: Predicted ceRNA/miRNA sponge mechanism involving hsa circ 21439/miR-26b/EphA2 and hsa circ 21439/miR-335/SOX4 axes.
Biological pathway or process:

metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

potential diagnosis and therapy targets for BCLM
Description:

hsa circ 21439 was the most significantly upregulated circRNA in breast cancer liver metastasis tissues and 231LM cells. The study predicts that it may act as a miRNA sponge through miR-26b/EphA2 and miR-335/SOX4-related axes and may promote tumor metastasis, suggesting potential diagnostic or therapeutic relevance for BCLM.
Confidence score:

0.6513
Other information
Title:

The potential targets for metastases: a study on altered circular RNA profile in breast cancer liver metastases.

Journal: Epigenomics
Published: 2019
PubMed ID: 31293174
Study type:

combined biological and clinical study
Data availability: Supplementary Table 1; Supplementary Table 2; Supplementary Table 3; Supplementary Table 4; Supplementary Table 5; Supplementary Figure 1; Supplementary Figure 2
Code availability: -