circRNA basic information
circBase ID: hsa_circ_0020460
Name: hsa_circ_DOCK1
Synonym: circ_0020460 / circDOCK1
Host Gene: DOCK1
Genomic location(hg19): chr10:128850944-128860040:+
Genomic location(hg38): chr10:127052680-127061776:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissue; normal tissue
Cell lines:

HeLa; CaSki; Ect1/E6E7; HUVECs
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCL1
Associated microRNA: miR-485-3p
Biological function: promotes proliferation, migration, invasion and angiogenesis; inhibits apoptosis; promotes tumor growth in vivo
Molecular mechanism: ceRNA mechanism: circ_0020460 sponges miR-485-3p to relieve repression of CXCL1
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0020460 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion, angiogenesis) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponging miR-485-3p, thereby increasing CXCL1 expression and promoting tumor growth in a CaSki xenograft model.
Confidence score:

0.8175
Other information
Title:

Circ_0020460 drives tumorigenesis in cervical cancer through miR-485-3p sponging.

Journal: Discover oncology
Published: 2024
PubMed ID: 38536591
Study type:

combined biological and clinical study
Data availability: GSE102686; GSE63678; 10.1007/s12672-024-00933-1
Code availability: -