| Expression pattern: |
UP |
| Associated gene: |
U2AF2, CEP70-160aa, PKM2, STAT3 |
| Associated microRNA: |
- |
| Biological function: |
Inhibits HCC proliferation, migration, invasion and metastasis (tumor-suppressive/anti-carcinogenic effects). |
| Molecular mechanism: |
circCEP70 encodes CEP70-160aa, which binds PKM2 and blocks its nuclear translocation, reducing nuclear STAT3 phosphorylation and downstream STAT3 target gene activation. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); JAK/STAT (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); RIP (RNA Immunoprecipitation); Co-IP; RNA-seq; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model |
| Clinical significance: |
High circCEP70 expression correlates with improved survival; low circCEP70 is an independent prognostic risk factor. |
| Description: |
circCEP70 is up-regulated in cirrhotic-background HCC and is associated with better patient survival. It suppresses HCC proliferation and metastasis mainly by encoding the protein CEP70-160aa, which binds PKM2, blocks PKM2 nuclear translocation, and reduces nuclear STAT3 phosphorylation within the JAK/STAT pathway context; U2AF2 negatively regulates circCEP70 biogenesis via binding flanking introns. |
| Confidence score: |
0.8748 |