circRNA basic information
circBase ID: hsa_circ_0001165
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr20:46252654-46262380:+
Genomic location(hg38): chr20:47623910-47633636:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

PC-3M IE8; PC-3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: TNF
Associated microRNA: hsa-miR-187-3p
Biological function: May induce EMT in prostate cancer cells by regulating TNF expression through hsa-miR-187-3p.
Molecular mechanism: Predicted circRNA-miRNA-mRNA regulatory network in which hsa_circ_0001165 may regulate TNF expression through hsa-miR-187-3p.
Biological pathway or process:

EMT (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; circRNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001165 was differentially expressed in the IFN-gamma-induced prostate cancer EMT model and validated by qPCR. The study predicts that it may promote EMT by regulating TNF through hsa-miR-187-3p in a circRNA-miRNA-mRNA network.
Confidence score:

0.4943
Other information
Title:

Screening and identification of epithelial-to-mesenchymal transition-related circRNA and miRNA in prostate cancer.

Journal: Pathology, research and practice
Published: 2020
PubMed ID: 31882179
Study type:

biological research
Data availability: Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.prp.2019.152784
Code availability: -