| Expression pattern: |
UP |
| Associated gene: |
TFAP4, Ago2 |
| Associated microRNA: |
miR-92a-2-5p |
| Biological function: |
promotes gastric cancer cell proliferation, migration, invasion and tumor growth in vivo |
| Molecular mechanism: |
circ_0006988 acts as a sponge for miRNA-92a-2-5p and upregulates TFAP4 expression, promoting malignant progression of gastric cancer |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0006988 is promising to be a target for GC treatment |
| Description: |
circ_0006988 is up-regulated in gastric cancer tissues and cell lines. It promotes GC cell proliferation, migration, invasion and xenograft tumor growth by sponging miRNA-92a-2-5p and increasing TFAP4 expression, suggesting a potential therapeutic target role in GC. |
| Confidence score: |
0.7756 |