circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: CircHIPK3 / Circ HIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent normal tissues; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker potential; expression correlates with tumor size
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Upregulated in BC tissues and plasma; diagnostic AUC 0.8087; associated with tumor size; improved sensitivity/specificity when combined with CA-15-3 and CEA
Description:

circHIPK3 (hsa_circ_0000284) is up-regulated in breast cancer tissues and patient plasma. It shows diagnostic utility (AUC 0.8087) and its high expression is associated with larger tumor size; combining it with CA-15-3 and CEA improves diagnostic performance.
Confidence score:

0.5963
Other information
Title:

Evaluation of CircHIPK3 biomarker potential in breast cancer.

Journal: Practical laboratory medicine
Published: 2025
PubMed ID: 40226123
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author, [S.M], upon reasonable request.
Code availability: -