| Expression pattern: |
DS |
| Associated gene: |
ABCA3, VAMP1, APLN, RP1-191J18 |
| Associated microRNA: |
miR-520a-5p, miR-1293, miR-378a-5p |
| Biological function: |
May participate in ceRNA regulatory mechanisms associated with EGFR mutations in NSCLC and may help predict EGFR mutations; circ_000373 was linked to ABCA3, VAMP1, and APLN-related ceRNA pathways. |
| Molecular mechanism: |
ceRNA mechanism involving circ_000373/miRNA/mRNA axes, including circ_000373/miR-520a-5p/ABCA3, circ_000373/miR-1293/VAMP1, and circ_000373/miR-378a-5p/APLN. |
| Biological pathway or process: |
ceRNA regulation (other); drug resistance (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
The key RNAs in the ceRNA network may be used as promising biomarkers for predicting EGFR mutations in NSCLC. |
| Description: |
circ_000373 was identified as a differentially expressed circRNA involved in ceRNA networks associated with EGFR mutation mechanisms in NSCLC. The paper proposes circ_000373-related axes with miR-520a-5p/ABCA3, miR-1293/VAMP1, and miR-378a-5p/APLN, and suggests that key RNAs in this network may predict EGFR mutations. |
| Confidence score: |
0.1768 |