circRNA basic information
circBase ID: hsa_circ_0049487
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr19:11657489-11657784:+
Genomic location(hg38): chr19:11546674-11546969:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

colorectal adenoma tissue; CRC tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ALPK3, FOXN3, TCF21
Associated microRNA: hsa-miR-17-5p, hsa-miR-20a-5p
Biological function: May play roles in both colorectal adenoma and CRC and serve as an early predictive biomarker discriminating adenoma/CRC from adjacent normal tissues.
Molecular mechanism: ceRNA mechanism (miRNA sponging) involving hsa-miR-17-5p and hsa-miR-20a-5p to regulate downstream mRNAs.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation; ROC Analysis
Clinical significance:

ROC curve analysis identified hsa_circ_0049487 as a possible novel biomarker predicting the transition from colonic adenoma to cancer; it could discriminate colorectal adenoma/CRC from adjacent normal tissues.
Description:

hsa_circ_0049487 is downregulated in both colorectal adenoma and colorectal cancer tissues versus adjacent normal tissues. It is part of a predicted circRNA-related ceRNA network (including sponging hsa-miR-17-5p and hsa-miR-20a-5p to affect downstream mRNAs such as ALPK3/FOXN3/TCF21) and shows diagnostic value for discriminating adenoma/CRC from normal tissues.
Confidence score:

0.5047
Other information
Title:

Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC.

Journal: Molecular therapy. Nucleic acids
Published: 2020
PubMed ID: 32145677
Study type:

combined biological and clinical study
Data availability: https://doi.org/10.1016/j.omtn.2020.01.031
Code availability: -