circRNA basic information
circBase ID: hsa_circ_0000519
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr14:20811436-20811534:-
Genomic location(hg38): chr14:20343277-20343375:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: CDH2
Associated microRNA: hsa-mir-204
Biological function: unknown
Molecular mechanism: ceRNA network mechanism (circRNA-miRNA-mRNA regulatory module) involving hsa-mir-204 and CDH2
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

may serve as a future therapeutic biomarker
Description:

This study identified hsa_circ_0000519 as a key differentially expressed circRNA in breast cancer and placed it in a ceRNA module with hsa-mir-204 and the hub gene CDH2. The authors suggest it may be important in breast cancer pathogenesis and a potential therapeutic biomarker.
Confidence score:

0.1768
Other information
Title:

Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.

Journal: Medicine
Published: 2019
PubMed ID: 31725681
Study type:

bioinformatics study
Data availability: GSE101123; TCGA
Code availability: -