| Expression pattern: |
UP |
| Associated gene: |
TNFAIP8 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
circPIM3 promotes Tax resistance and proliferation, supports cell cycle progression, inhibits apoptosis, and reduces Tax sensitivity in Tax-resistant NSCLC cells. |
| Molecular mechanism: |
circPIM3 functions as a miRNA sponge for miR-338-3p and regulates TNFAIP8 expression through the miR-338-3p/TNFAIP8 axis. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circPIM3 is associated with Tax resistance in NSCLC, and high circPIM3 expression is associated with worse overall survival. |
| Description: |
This study identifies circPIM3 as an up-regulated circRNA in Tax-resistant NSCLC tissues and cells. circPIM3 promotes Tax resistance and malignant phenotypes by sponging miR-338-3p and increasing TNFAIP8, while circPIM3 silencing enhances Tax sensitivity in vitro and in a xenograft model. High circPIM3 expression is associated with poorer overall survival. |
| Confidence score: |
0.7793 |