| Expression pattern: |
UP |
| Associated gene: |
beta-catenin |
| Associated microRNA: |
miR-142-5p |
| Biological function: |
Promotes proliferation, migration and invasion and inhibits apoptosis in esophageal cancer cells. |
| Molecular mechanism: |
Acts as a miRNA sponge by directly binding miR-142-5p, leading to decreased beta-catenin expression (Wnt/beta-catenin-related). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); Wnt/beta-catenin (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Expression was reported in patient tumor vs adjacent tissues; authors state it provides clinical significance. |
| Description: |
hsa_circ_0001615 is up-regulated in esophageal cancer tissues and cell lines. Its knockdown suppresses proliferation, colony formation, migration and invasion, and promotes apoptosis by directly sponging miR-142-5p and reducing beta-catenin expression, implicating a miR-142-5p/beta-catenin (Wnt/beta-catenin-related) mechanism. |
| Confidence score: |
0.7872 |