circRNA basic information
circBase ID: hsa_circ_0004099
Name: hsa_circ_DENND5A
Synonym: hsa_circRNA_100759
Host Gene: DENND5A
Genomic location(hg19): chr11:9225206-9229179:-
Genomic location(hg38): chr11:9203659-9207632:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0800504
MONDO name: idiopathic pulmonary fibrosis
Disease details: Idiopathic Pulmonary Fibrosis / IPF
Disease DO ID:
 -
Disease MeSH ID:
 D054990
Disease NCIt ID:
 C35716
Disease ICD11 ID:
 1074069640
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for IPF.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Increased in plasma exosomes of IPF patients with diagnostic value (ROC AUC 0.887).
Description:

hsa_circ_0004099 is up-regulated in plasma exosomes of IPF patients and shows good diagnostic performance by ROC analysis. No downstream mechanism was investigated for this circRNA in the study.
Confidence score:

0.4679
Other information
Title:

Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction.

Journal: Journal of translational medicine
Published: 2024
PubMed ID: 38462601
Study type:

combined biological and clinical study
Data availability: 10.1186/s12967-024-05034-9
Code availability: -