circRNA basic information
circBase ID: hsa_circ_0087391
Name: hsa_circ_AGTPBP1
Synonym: -
Host Gene: AGTPBP1
Genomic location(hg19): chr9:88284399-88327481:-
Genomic location(hg38): chr9:85669484-85712566:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: stage II/III colon cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

frozen tumor tissues; adjacent normal tissues
Cell lines:

SW620; HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes colon cancer cell migration
Molecular mechanism: Loss-of-function (shRNA knockdown) suggests a pro-migratory role; downstream mechanism not specified for this circRNA.
Biological pathway or process:

migration (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Transfection; Transwell Assay
Clinical significance:

Included in a four-circRNA-based cirScore that stratifies recurrence risk and is associated with shorter DFS and OS in high-risk (high cirScore) patients.
Description:

hsa_circ_0087391 is overexpressed in recurrent stage II/III colon cancer and colon cancer cells. Its knockdown reduces cell migration in vitro, and it is part of a four-circRNA prognostic cirScore associated with worse survival when high.
Confidence score:

0.8004
Other information
Title:

A circRNA signature predicts postoperative recurrence in stage II/III colon cancer.

Journal: EMBO molecular medicine
Published: 2019
PubMed ID: 31475771
Study type:

combined biological and clinical study
Data availability: SRA551560 (PRJNA551560); PRJCA001113
Code availability: https://github.com/likelet/CircRNA_colon_recurrent_prediction; https://github.com/likelet/RNAseqPipe