| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, N-cadherin, vimentin, beta-catenin, AKT, PI3K, caspase 3, bcl-2, Bax |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration, invasion and EMT; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
activates PI3K/AKT signaling; promotes EMT; regulates apoptosis-related proteins |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); PI3K/AKT (promotes); apoptosis (inhibits) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
the expression level of hsa_circ_0002238 has good diagnostic accuracy (AUC = 0.765) and correlates with patient gender |
| Description: |
hsa_circ_0002238 is up-regulated in colorectal cancer tissues and cell lines, localizes mainly in the cytoplasm, and promotes malignant phenotypes (proliferation, migration, invasion, EMT) while inhibiting apoptosis. It is associated with increased PI3K/AKT pathway activation and shows potential diagnostic value (ROC AUC 0.765) in a small clinical cohort. |
| Confidence score: |
0.6921 |