circRNA basic information
circBase ID: hsa_circ_0032777
Name: hsa_circ_AHSA1
Synonym: circAHSA1
Host Gene: AHSA1
Genomic location(hg19): chr14:77930940-77934851:+
Genomic location(hg38): chr14:77464597-77468508:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent non-tumorous tissues; serum
Cell lines:

AGS; HGC-27; BGC-823; MKN-1; SGC-7901; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-647, miR-661
Biological function: promotes proliferation, migration, and invasion; suppresses apoptosis; induces cell-cycle progression
Molecular mechanism: Potential ceRNA mechanism with predicted binding to miR-647 and miR-661 (bioinformatic prediction only).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; DeLong tests; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis
Clinical significance:

Serum circAHSA1 discriminates GC from healthy controls and gastritis patients and correlates with lymph node metastasis, differentiation status, and TNM stage.
Description:

circAHSA1 (hsa_circ_0032777), derived from AHSA1, is up-regulated in gastric cancer tissues, serum, and GC cell lines. It promotes malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis with effects on cell-cycle distribution. It is mainly cytoplasmic and is predicted (bioinformatically) to interact with miR-647 and miR-661, and it shows diagnostic utility in serum (ROC/AUC) and association with clinicopathologic features.
Confidence score:

0.8226
Other information
Title:

Circular RNA circAHSA1 serves as a stable serum biomarker for the diagnosis and progression of gastric cancer.

Journal: Translational oncology
Published: 2026
PubMed ID: 41330006
Study type:

combined biological and clinical study
Data availability: GSE121445; Supplementary File S1
Code availability: Supplementary File S1