| Expression pattern: |
DN |
| Associated gene: |
LRIG1, E-cadherin, N-cadherin, Vimentin, Ago2 |
| Associated microRNA: |
miR-214-3p |
| Biological function: |
Suppresses bladder carcinoma cell growth, migration and invasion; promotes apoptosis; decreases tumor growth and metastasis in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-214-3p to enhance LRIG1 expression |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
Low circLRIG1 expression was associated with poor patient prognosis. |
| Description: |
circLRIG1 is down-regulated in bladder carcinoma and mainly localizes to the cytoplasm. It suppresses proliferation and metastasis and promotes apoptosis by acting as a ceRNA that sponges miR-214-3p, thereby increasing LRIG1 expression; low circLRIG1 is associated with worse overall survival. |
| Confidence score: |
0.8661 |