circRNA basic information
circBase ID: hsa_circ_0005280
Name: hsa_circ_SCN7A
Synonym: novel_circ_0005280
Host Gene: SCN7A
Genomic location(hg19): chr2:168869143-168931741:-
Genomic location(hg38): chr2:168012633-168075231:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumor tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for NSCLC diagnosis and prognosis.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic value (AUC 0.944; sensitivity 85.2%; specificity 95.1%) and low expression is associated with worse prognosis in NSCLC.
Description:

novel_circ_0005280 (host gene SCN7A) is down-regulated in NSCLC tumor tissues versus adjacent tissues. It shows strong diagnostic performance (ROC AUC 0.944) and lower expression is associated with worse overall survival, suggesting utility as a diagnostic and prognostic biomarker.
Confidence score:

0.636
Other information
Title:

Reduced expression of circRNA novel_circ_0005280 and its clinical value in the diagnosis of non-small cell lung cancer.

Journal: Journal of thoracic disease
Published: 2020
PubMed ID: 33447417
Study type:

combined biological and clinical study
Data availability: http://dx.doi.org/10.21037/jtd-20-2977
Code availability: -