| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
ｍｉＲ•２１７ |
| Biological function: |
circABCB10 promotes colorectal cancer cell proliferation, migration, invasion and xenograft growth, inhibits apoptosis, and decreases radiosensitivity; silencing circABCB10 has the opposite effects. |
| Molecular mechanism: |
circABCB10 targets and negatively regulates miR-217; silencing circABCB10 up-regulates miR-217, thereby inhibiting malignant phenotypes and increasing radiosensitivity. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Colony Formation Assay; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circABCB10 may be a potential target for diagnosis, treatment and radiosensitization in colorectal cancer. |
| Description: |
In this study, circABCB10 was up-regulated in colorectal cancer tissues and cell lines. Silencing circABCB10 inhibited SW480 cell proliferation, migration, invasion and xenograft growth, promoted apoptosis, and increased radiosensitivity. Mechanistically, circABCB10 acted through miR-217 regulation, suggesting its potential as a therapeutic and radiosensitizing target in colorectal cancer. |
| Confidence score: |
0.6536 |