| Expression pattern: |
UP |
| Associated gene: |
CCNE2, AGO2, p-Rb, E2F1, c-myc |
| Associated microRNA: |
hsa-miR-577 |
| Biological function: |
Promotes HCC cell viability/proliferation, colony formation, migration and invasion; inhibits apoptosis; promotes xenograft tumor growth. |
| Molecular mechanism: |
Acts as a miR-577 sponge to positively regulate CCNE2 expression; associated with Ago2-containing RISC; affects downstream p-Rb/E2F1/c-myc. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; ISH (In Situ Hybridization); RNase R Treatment; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High circ-CSPP1 expression predicted poor prognosis and was associated with larger tumor size and advanced TNM stage in HCC patients. |
| Description: |
circ-CSPP1 (hsa_circ_0001806) is upregulated in HCC tissues and cell lines and predicts poorer overall survival. Functionally, it promotes proliferation, colony formation, migration, invasion and xenograft growth. Mechanistically, circ-CSPP1 sponges miR-577 to increase CCNE2 expression, influencing downstream cell-cycle related proteins (e.g., p-Rb/E2F1/c-myc). |
| Confidence score: |
0.8457 |