| Expression pattern: |
UP |
| Associated gene: |
MSI1 |
| Associated microRNA: |
miR-34c-5p |
| Biological function: |
Circ_KIAA1199 functions as an oncogene in CRC, promoting cell proliferation, survival, migration, invasion and xenograft tumor growth while inhibiting apoptosis. |
| Molecular mechanism: |
Circ_KIAA1199 acts as a competing endogenous RNA sponge for miR-34c-5p, thereby relieving miR-34c-5p-mediated inhibition of MSI1 and increasing MSI1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; Colony Formation Assay; EdU Staining; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
Circ_KIAA1199 is up-regulated in colorectal cancer tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses CRC cell proliferation, survival, migration, invasion and xenograft tumor growth, partly through release of miR-34c-5p and consequent inhibition of MSI1. |
| Confidence score: |
0.8175 |