| Expression pattern: |
UP |
| Associated gene: |
YWHAH |
| Associated microRNA: |
miR-1178-3p |
| Biological function: |
Promotes PTC cell proliferation, migration, invasion, and angiogenesis; inhibits apoptosis; promotes xenograft tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge (decoy) for miR-1178-3p to increase YWHAH expression (validated by dual-luciferase; functional rescue with miR-1178-3p inhibitor). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0000144 expression was associated with TNM stage and lymph node metastasis of PTC patients. |
| Description: |
circ_0000144 is up-regulated in papillary thyroid cancer tissues/cells and promotes malignant phenotypes and angiogenesis. It functions as a ceRNA by sponging miR-1178-3p, thereby increasing YWHAH expression and enhancing tumor growth in vitro and in a xenograft model. |
| Confidence score: |
0.6919 |