circRNA basic information
circBase ID: hsa_circ_0001721
Name: hsa_circ_CDK14
Synonym: -
Host Gene: CDK14
Genomic location(hg19): chr7:90355880-90356126:+
Genomic location(hg38): chr7:90726566-90726812:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

LNCaP; 22Rv1; DU145; BPH1; PC-3; BPH1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-221
Biological function: unknown
Molecular mechanism: Predicted miRNA binding (miR-221).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001721 (host gene CDK14) is up-regulated in highly enzalutamide-resistant LNCaP clone 1 versus sensitive control cells. The study predicts miR-221 as a binding miRNA, but does not experimentally validate a downstream target or pathway.
Confidence score:

0.3684
Other information
Title:

Circular RNAs are differentially expressed in prostate cancer and are potentially associated with resistance to enzalutamide.

Journal: Scientific reports
Published: 2019
PubMed ID: 31341219
Study type:

biological research
Data availability: GSE118959
Code availability: -