| Expression pattern: |
UP |
| Associated gene: |
FASN |
| Associated microRNA: |
miR-637 |
| Biological function: |
promotes cell proliferation, colony formation, migration, and invasion in vitro; promotes tumor growth in vivo; promotes fatty acid metabolism |
| Molecular mechanism: |
circHIPK3 acts as a ceRNA to sponge miR-637, relieving repression of FASN and thereby regulating fatty acid metabolism in ESCC cells |
| Biological pathway or process: |
fatty acid metabolism (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Oil Red O Staining; Western Blot; In Vivo Animal Model |
| Clinical significance: |
may be a potential biomarker and therapeutic target for ESCC in the clinic |
| Description: |
circHIPK3 is up-regulated in ESCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft tumor growth. It functions mainly in the cytoplasm as a ceRNA that sponges miR-637 to de-repress FASN, enhancing fatty acid metabolism; ASO-mediated circHIPK3 inhibition suppresses ESCC, suggesting therapeutic potential. |
| Confidence score: |
0.7966 |