circRNA basic information
circBase ID: hsa_circ_0079226
Name: hsa_circ_FOXK1
Synonym: circ_0079226
Host Gene: FOXK1
Genomic location(hg19): chr7:4721929-4795175:+
Genomic location(hg38): chr7:4682298-4755544:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous tissues; adjacent noncancerous tissues; xenograft tumors
Cell lines:

MKN74; NCI-N87; KATO III; MKN-7; HGC-27; GES-1; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FOXK1, FAK, AKT, p-AKT
Associated microRNA: miR-155-5p
Biological function: promotes GC cell proliferation, migration, invasion, and in vivo tumor growth
Molecular mechanism: Acts as a miRNA sponge for miR-155-5p, relieving repression of FOXK1 and activating downstream FAK/AKT signaling.
Biological pathway or process:

AKT/mTOR (promotes); PI3K/AKT/mTOR (other); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0079226 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion, EMT-like changes, and xenograft tumor growth. Mechanistically, it sponges miR-155-5p to derepress FOXK1 and enhance downstream FAK/AKT signaling.
Confidence score:

0.7373
Other information
Title:

Circular RNA Circ_0079226 Plays an Oncogenic Role in Gastric Cancer via the miR-155-5p/FOXK1/AKT Pathway.

Journal: Analytical cellular pathology (Amsterdam)
Published: 2025
PubMed ID: 39981141
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -