| Expression pattern: |
UP |
| Associated gene: |
PTBP3, Ago2 |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
promotes proliferation, migration, EMT and glycolysis; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circSEPT9 sponges miR-625-5p to up-regulate PTBP3 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); EMT (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
- |
| Description: |
circSEPT9 is up-regulated in breast cancer tissues/cells and acts as an oncogenic circRNA. It promotes proliferation, migration, EMT and glycolysis and inhibits apoptosis by sponging miR-625-5p, thereby relieving repression of PTBP3 and supporting tumor growth in vivo. |
| Confidence score: |
0.795 |