| Expression pattern: |
UP |
| Associated gene: |
FOXM1, AGO2 |
| Associated microRNA: |
miR-671-5p |
| Biological function: |
CircRIP2 promotes NSCLC cell growth, proliferation, migration and metastasis, and acts as a tumor promoter associated with poorer OS and DFS. |
| Molecular mechanism: |
CircRIP2 acts as a miRNA sponge for miR-671-5p and facilitates FOXM1 expression through the circRIP2/miR-671-5p/FOXM1 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; BrdU; Transwell Assay; In Vivo Animal Model; Western Blot; Cohort Study; Survival Analysis |
| Clinical significance: |
High circRIP2 expression is associated with tumor size, nodule metastasis, AJCC stage, and predicts poorer OS and DFS in NSCLC patients. |
| Description: |
CircRIP2 is up-regulated in NSCLC tissues and cell lines and high expression predicts poorer OS and DFS. Functionally, it promotes NSCLC cell growth, proliferation, migration and metastasis. Mechanistically, cytoplasmic circRIP2 sponges miR-671-5p to relieve repression of FOXM1, forming the circRIP2/miR-671-5p/FOXM1 regulatory axis. |
| Confidence score: |
0.8005 |