circRNA basic information
circBase ID: hsa_circ_0004370
Name: hsa_circ_PRRX1
Synonym: circPRRX1 / hsa_circRNA_100385
Host Gene: PRRX1
Genomic location(hg19): chr1:170688866-170695542:+
Genomic location(hg38): chr1:170719725-170726401:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary human gastric tumors; paired noncancerous normal gastric specimens; adjacent normal gastric tissues; xenograft tumors
Cell lines:

HGC-27; AGS; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: NKAP
Associated microRNA: miR-596
Biological function: Exosomal circPRRX1 promotes gastric cancer cell proliferation, colony formation, migration, invasion, tumor growth, and reduces radiation sensitivity.
Molecular mechanism: Exosomal circPRRX1 acts as a ceRNA for miR-596 to upregulate NKAP expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); radioresistance (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model
Clinical significance:

Exosomal circPRRX1's ability to regulate gastric cancer progression may prove to be clinically useful.
Description:

circPRRX1 is up-regulated in human gastric cancer tissues and cell lines and can be transferred via exosomes derived from gastric cancer cells. Exosomal circPRRX1 promotes proliferation, colony formation, migration, invasion, and in vivo tumor growth while reducing radiation sensitivity. Mechanistically, it functions as a ceRNA for miR-596 to increase NKAP expression, forming an exosomal circPRRX1/miR-596/NKAP axis.
Confidence score:

0.7177
Other information
Title:

Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-kappaB activating protein.

Journal: Anti-cancer drugs
Published: 2022
PubMed ID: 36206097
Study type:

combined biological and clinical study
Data availability: GSE83521; Supplementary Table 1, Supplemental Digital Content 1, http://links.lww.com/ACD/A448
Code availability: -