| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circWDR25 is highly expressed in exosomes from tumor-activated hepatic stellate cells and in peritumoral tissues, correlates positively with HSC activation, and high peritumoral expression is associated with worse overall and tumor-free survival after curative resection. |
| Molecular mechanism: |
Exosome-mediated communication between tumor-activated hepatic stellate cells and hepatocellular carcinoma; the detailed mechanism was not defined. |
| Biological pathway or process: |
other pathway/process (promotes) |
| Detected method: |
H
M
|
| Validation methods: |
Microarray; ISH (In Situ Hybridization); Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High peritumoral circWDR25 expression is closely associated with poor prognosis and may serve as a reference indicator for prognosis evaluation and postoperative screening after curative resection in HCC. |
| Description: |
This study identified circWDR25 as the most prominently up-regulated circRNA in exosomes from HCC cell-activated LX-2 hepatic stellate cells. In peritumoral liver tissues from 288 HCC patients, circWDR25 expression correlated positively with alpha-SMA/HSC activation, and high expression was an independent risk factor for poor overall and tumor-free survival after curative resection. The authors suggest that exosome-derived circWDR25 may participate in HSC-HCC crosstalk and could serve as a prognostic and postoperative monitoring indicator. |
| Confidence score: |
0.5202 |