circRNA basic information
circBase ID: -
Name: hsa_circ_TFRC
Synonym: circRNA-TFRC
Host Gene: TFRC
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002050
MONDO name: depressive disorder
Disease details: T2DM with depression
Disease DO ID:
 1596
Disease MeSH ID:
 D003866
Disease NCIt ID:
 C2982
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood / Peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with insulin resistance and potentially contributes to more severe diabetes-related symptoms in DD compared with T2DM.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Proposed as a molecular target/biomarker candidate for studying DD and related mental disorders.
Description:

circRNA-TFRC is up-regulated in peripheral blood of DD (T2DM with depression) patients versus T2DM alone and is suggested to relate to more severe insulin resistance/diabetic symptoms in DD. No specific downstream miRNA/target axis was experimentally established in this study.
Confidence score:

0.1768
Other information
Title:

Relationships of Non-coding RNA with diabetes and depression.

Journal: Scientific reports
Published: 2019
PubMed ID: 31341180
Study type:

combined biological and clinical study
Data availability: The datasets used and analyzed during the current study are available from the first or corresponding authors on reasonable request.
Code availability: -