circRNA basic information
circBase ID: hsa_circ_0004951
Name: hsa_circ_TRPM7
Synonym: circTRPM7
Host Gene: TRPM7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HGC-27; AGS; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PBX3, AGO2, PCNA, CyclinD1, MMP-2, MMP-9, Bcl-2, Bax
Associated microRNA: miR-145-5p
Biological function: CircTRPM7 promotes growth, proliferation, migration, invasion and metastasis, and inhibits apoptosis in Sinomenine-treated gastric cancer cells.
Molecular mechanism: CircTRPM7 functions as a sponge for miR-145-5p, regulating the miR-145-5p/PBX3 axis in Sinomenine-treated gastric cancer cells.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

This study shows that Sinomenine reduces circTRPM7 expression in gastric cancer cells. CircTRPM7 counteracts Sinomenine's antitumor effects by promoting cell growth, proliferation, migration, invasion and metastasis while suppressing apoptosis, mainly through the circTRPM7/miR-145-5p/PBX3 regulatory axis.
Confidence score:

0.6966
Other information
Title:

Sinomenine regulates circTRPM7-related pathway to inhibit gastric cancer cell growth and metastasis.

Journal: Chemical biology & drug design
Published: 2023
PubMed ID: 37495546
Study type:

biological research
Data availability: available on request from the corresponding author; Supporting Information
Code availability: -