circRNA basic information
circBase ID: -
Name: hsa_circ_EIF6
Synonym: circular RNA eukaryotic translation initiation factor 6
Host Gene: EIF6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002108
MONDO name: thyroid cancer
Disease details: thyroid cancer
Disease DO ID:
 1781
Disease MeSH ID:
 -
Disease NCIt ID:
 C7510
Disease ICD11 ID:
 447433352
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TC tissues; paracancer tissues; tumor tissues
Cell lines:

HT-ori3; TPC-1; FRO; KTC3
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: LIPH, Ago2
Associated microRNA: miR-138-5p
Biological function: Facilitates TPC-1 cell proliferation and invasion; promotes tumorigenesis in vivo; circEIF6 silencing represses proliferative and invasive properties and tumor growth.
Molecular mechanism: circEIF6 functions as a ceRNA by competitively binding miR-138-5p to upregulate LIPH, thereby enhancing TPC-1 cell proliferation and invasion.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); EMT (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

circEIF6 upregulation is correlated with TC development and is linked to clinical TNM stage, lymph node metastasis, and tumor size.
Description:

circEIF6 is up-regulated in thyroid cancer tissues and cell lines and correlates with advanced clinicopathological features including TNM stage, lymph node metastasis, and tumor size. Functionally, circEIF6 promotes TPC-1 cell proliferation, invasion, EMT-related marker changes, and xenograft tumor growth. Mechanistically, circEIF6 acts as a ceRNA that sponges miR-138-5p to increase LIPH expression.
Confidence score:

0.8158
Other information
Title:

Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis.

Journal: Functional & integrative genomics
Published: 2023
PubMed ID: 37776372
Study type:

combined biological and clinical study
Data availability: GSE104006; GSE103996; available from the corresponding author on reasonable request; https:// doi. org/ 10. 1007/ s10142-023-01240-8
Code availability: -