circRNA basic information
circBase ID: -
Name: hsa_circ_RAD18
Synonym: circRAD18
Host Gene: RAD18
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000872
MONDO name: B-cell childhood acute lymphoblastic leukemia
Disease details: Pediatric B-cell acute lymphoblastic leukemia
Disease DO ID:
 0080146
Disease MeSH ID:
 -
Disease NCIt ID:
 C9140
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow blood; bone marrow mononuclear cells; cord blood mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for differentiating B-ALL patients from T-ALL patients and healthy subjects.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential diagnostic biomarker due to its ability to differentiate B-ALL patients from T-ALL patients and healthy subjects; not a prognostic marker for risk stratification in the tested cohort.
Description:

circRAD18 is significantly overexpressed in pediatric B-ALL patients compared with T-ALL patients and healthy subjects, with RT-qPCR validation in clinical samples. The study supports its potential diagnostic biomarker role, but it did not stratify risk groups and no functional mechanism was investigated.
Confidence score:

0.5135
Other information
Title:

Identification of a circular RNA isoform of WASHC2A as a prognostic factor for high-risk paediatric B-ALL patients.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2024
PubMed ID: 38917755
Study type:

clinical study
Data availability: Data will be made available on request; Supplementary Dataset 1; Supplementary Dataset 2; Supplementary Dataset 3; doi:10.1016/j.biopha.2024.116903
Code availability: -