circRNA basic information
circBase ID: hsa_circ_0001361
Name: hsa_circ_FNDC3B
Synonym: circ-FNDC3B
Host Gene: FNDC3B
Genomic location(hg19): chr3:171830241-171851336:+
Genomic location(hg38): chr3:172112451-172133546:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005072
MONDO name: neuroblastoma
Disease details: neuroblastoma / NB
Disease DO ID:
 769
Disease MeSH ID:
 D009447
Disease NCIt ID:
 C3270
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NB tissues; normal tissues
Cell lines:

IMR-32; SK-N-SH; HUVEC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIM2
Associated microRNA: miR-490-5p
Biological function: Promotes NB cell proliferation, migration, invasion, metastasis, glycolytic metabolism and tumor growth; knockdown suppresses malignant behaviors and glycolysis.
Molecular mechanism: Hsa_circ_0001361 functions as a ceRNA/miRNA sponge for miR-490-5p, relieving miR-490-5p-mediated repression of TRIM2 and inducing TRIM2 upregulation.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Hsa_circ_0001361 was abnormally upregulated in NB patient tissues, but no diagnostic or prognostic performance was reported.
Description:

Hsa_circ_0001361 is up-regulated in neuroblastoma tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, glycolysis and xenograft tumor growth by sponging miR-490-5p and upregulating TRIM2.
Confidence score:

0.8175
Other information
Title:

Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.

Journal: Metabolic brain disease
Published: 2023
PubMed ID: 36920626
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request; supplementary material available at https:// doi. org/ 10. 1007/ s11011-023-01197-4.
Code availability: -