| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
High-confidence PD-associated blood circRNA (not driven by cell composition or medication); explored for biological pathway relevance via miRNA analyses. |
| Molecular mechanism: |
Predicted miRNA targeting (in-silico) with circRNA-miRNA correlations; downstream pathway enrichment via miRNAs. |
| Biological pathway or process: |
Hippo/YAP (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Identified and replicated as a high-confidence blood circRNA associated with PD. |
| Description: |
circSUZ12 is down-regulated in PD blood and is among the study’s five high-confidence PD-associated circRNAs. The study further contextualized it via in-silico miRNA target prediction, circRNA-miRNA correlation filtering, and pathway enrichment analyses. |
| Confidence score: |
0.348 |