| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic and prognostic biomarker for gastric cancer; increased circSLIT2 RNA accumulation is associated with distant tumor metastases, while functional assays were not performed. |
| Molecular mechanism: |
Underlying mechanisms were not experimentally explored in this study. |
| Biological pathway or process: |
metastasis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis |
| Clinical significance: |
Increased plasma circSLIT2 may serve as a biomarker for GC diagnosis and prognosis; high circSLIT2 levels in plasma and tumor tissues were observed in most patients who died during follow-up. |
| Description: |
circSLIT2 is up-regulated in gastric cancer tissues and plasma, with plasma levels positively correlated with tumor-tissue levels. The study supports circSLIT2 as a diagnostic and prognostic biomarker for gastric cancer, with high expression associated with poorer survival and distant metastasis, but it did not experimentally define a molecular mechanism. |
| Confidence score: |
0.4992 |