circRNA basic information
circBase ID: -
Name: hsa_circ_PTPRA
Synonym: circRNA_PTPRA
Host Gene: PTPRA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissue; adjacent normal tissue
Cell lines:

A549; NCI-H23; BEAS2B; 293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: cyclin D1
Associated microRNA: miR-582-3p
Biological function: suppresses proliferation; induces apoptosis
Molecular mechanism: acts as a miRNA sponge to downregulate miR-582-3p
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

circRNA_PTPRA is down-regulated in lung adenocarcinoma tissues/cells and functions as a tumor suppressor by inhibiting proliferation and promoting apoptosis. Mechanistically, it sponges miR-582-3p and negatively regulates its expression, and miR-582-3p overexpression reverses circRNA_PTPRA’s effects.
Confidence score:

0.6996
Other information
Title:

CircRNA protein tyrosine phosphatase receptor type a suppresses proliferation and induces apoptosis of lung adenocarcinoma cells via regulation of microRNA-582-3p.

Journal: Bioengineered
Published: 2022
PubMed ID: 35549985
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.; https://doi.org/10.1080/21655979.2022.2073319
Code availability: -