| Expression pattern: |
UP |
| Associated gene: |
Bcl-2, caspase-3 |
| Associated microRNA: |
miR-1248 |
| Biological function: |
promotes proliferation, migration, invasion, and metastasis; inhibits apoptosis; associated with gastric cancer progression and diagnostic monitoring |
| Molecular mechanism: |
circXPO1 acts as a miRNA sponge by binding miR-1248; knockdown affects apoptosis-related proteins caspase-3 and Bcl-2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; EdU Staining; Transwell Assay; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circXPO1 may serve as a diagnostic biomarker for gastric cancer; higher plasma circXPO1 is related to lymph node metastasis, TNM stage, differentiation, and dynamic postoperative monitoring |
| Description: |
circXPO1 (hsa_circ_0001017), derived from XPO1, is up-regulated in gastric cancer tissues, plasma, and cell lines. It promotes GC cell proliferation, migration, invasion, and metastasis while inhibiting apoptosis, and it binds miR-1248 as a miRNA sponge. Plasma circXPO1 shows diagnostic value for distinguishing GC patients from healthy donors and may support dynamic monitoring after surgery. |
| Confidence score: |
0.8407 |