circRNA basic information
circBase ID: hsa_circ_0006624
Name: hsa_circ_ADAMTS12
Synonym: -
Host Gene: ADAMTS12
Genomic location(hg19): chr5:33881223-33881585:-
Genomic location(hg38): chr5:33881118-33881480:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ADAMTS12
Associated microRNA: -
Biological function: Associated with reduced infiltration of surrounding tissues (lower expression observed in infiltrating tumors).
Molecular mechanism: -
Biological pathway or process:

invasion (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

Lower hsa_circ_0006624 expression was associated with tumors infiltrating surrounding tissues; hsa_circ_0006624 expression correlated with ADAMTS12 expression.
Description:

hsa_circ_0006624 (ADAMTS12-derived) was down-regulated in NSCLC tumors that infiltrated surrounding tissues and its expression correlated with ADAMTS12 mRNA in clinical lung tissue samples. The study did not experimentally establish specific miRNA targets or downstream pathways for this circRNA.
Confidence score:

0.4685
Other information
Title:

ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis.

Journal: International journal of molecular sciences
Published: 2024
PubMed ID: 38339175
Study type:

combined biological and clinical study
Data availability: The data presented in this study are available on request from the corresponding author.
Code availability: -