circRNA basic information
circBase ID: hsa_circ_0000204
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:1117078-1118233:+
Genomic location(hg38): chr10:1071138-1072293:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-cancerous tissues
Cell lines:

HepG2; Hep3B; SMMC7721
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: KLF6
Associated microRNA: miR-191
Biological function: sponges miR-191 and weakens the proliferative phenotype driven by high miR-191 in HCC cells
Molecular mechanism: ceRNA/miRNA sponge: hsa_circ_0000204 binds miR-191 to inactivate it, involved in the hsa_circ_0000204/miR-191/KLF6 network
Biological pathway or process:

proliferation (inhibits); cell cycle (inhibits); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RT-qPCR; Transfection; CCK8
Clinical significance:

-
Description:

In HCC, hsa_circ_0000204 is downregulated (per circRNA microarray dataset) and functions as a sponge for miR-191. By binding and inactivating miR-191, it alleviates the miR-191-driven proliferative/cell-cycle phenotype, within the hsa_circ_0000204/miR-191/KLF6 regulatory network.
Confidence score:

0.6157
Other information
Title:

MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis.

Journal: Cell proliferation
Published: 2019
PubMed ID: 31334580
Study type:

combined biological and clinical study
Data availability: GSE94508; TCGA-LIHC; GSE10694; GSE6857
Code availability: -