circRNA basic information
circBase ID: hsa_circ_0072676
Name: hsa_circ_ADAMTS6
Synonym: -
Host Gene: ADAMTS6
Genomic location(hg19): chr5:64556426-64748043:-
Genomic location(hg38): chr5:65260599-65452216:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: ADAMTS6
Associated microRNA: -
Biological function: -
Molecular mechanism: Predicted circRNA/miRNA/mRNA interaction potentially influencing ADAMTS6 transcript stability (not supported by observed circRNA-host correlation).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

hsa_circ_0072676 expression differed by histopathological subtype (higher in large-cell lung cancer than squamous cell carcinoma).
Description:

hsa_circ_0072676 (ADAMTS6-derived) showed subtype-associated dysregulation in NSCLC, with higher expression in large-cell lung cancer compared to squamous cell carcinoma. Its predicted mechanism involved a potential circRNA/miRNA/mRNA interaction impacting ADAMTS6 transcript stability, but this was not supported by circRNA-host expression correlation in this cohort.
Confidence score:

0.4685
Other information
Title:

ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis.

Journal: International journal of molecular sciences
Published: 2024
PubMed ID: 38339175
Study type:

combined biological and clinical study
Data availability: The data presented in this study are available on request from the corresponding author.
Code availability: -