| Expression pattern: |
DN |
| Associated gene: |
ST5 |
| Associated microRNA: |
miR-378 |
| Biological function: |
Exosomal circIFNGR2 inhibits OVCA cell proliferation, migration, invasion, EMT, tumor growth and metastatic progression. |
| Molecular mechanism: |
CAF-derived exosomes transfer circIFNGR2 into OVCA cells; circIFNGR2 functions as a ceRNA/sponge for miR-378 to upregulate ST5 and suppress malignant progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circIFNGR2 showed potential diagnostic value for OVCA, with ROC AUC 0.9398 and sensitivity 100%; lower circIFNGR2 was described as a potential independent risk factor. |
| Description: |
circIFNGR2 is down-regulated in OVCA tissues and cell lines and can be transferred from CAF-derived exosomes into OVCA cells. It suppresses OVCA proliferation, migration, invasion, EMT, tumor growth and metastatic progression through a circIFNGR2/miR-378/ST5 ceRNA axis, and it shows potential diagnostic value for OVCA. |
| Confidence score: |
0.8615 |