| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-514a-5p, hsa-miR-514b-5p, hsa-miR-26a-1-3p, hsa-miR-937-5p |
| Biological function: |
Potential tumor suppressor and biomarker for diagnosis and dynamic monitoring in gastric cancer; may participate in regulating gastric cancer progression as a miRNA sponge. |
| Molecular mechanism: |
Likely ceRNA/miRNA sponge (predicted downstream miRNAs); post-transcriptional regulation implied by cytoplasmic localization. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Serum hsa_circ_0000231 shows diagnostic value for GC (AUC=0.781) and increases postoperatively, suggesting utility for dynamic monitoring; low expression correlates with TNM stage, lymph node metastasis, and neurovascular invasion. |
| Description: |
hsa_circ_0000231 is down-regulated in gastric cancer serum, tissues, and GC cell lines, and its postoperative increase supports use in dynamic monitoring. It shows diagnostic utility (ROC AUC 0.781) and is mainly cytoplasmic, suggesting a ceRNA/miRNA-sponge role with predicted miRNA partners (e.g., hsa-miR-26a-1-3p). |
| Confidence score: |
0.6981 |