circRNA basic information
circBase ID: hsa_circ_0089172
Name: hsa_circ_NUP214
Synonym: -
Host Gene: NUP214
Genomic location(hg19): chr9:134049441-134053797:+
Genomic location(hg38): chr9:131174054-131178410:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; plasma
Cell lines:

HepG2; Huh7; Hep3B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDC7, CCNB1, CENPU, ASPM, ECT2, NDC80
Associated microRNA: hsa-miR-4524a-3p
Biological function: unknown
Molecular mechanism: Putative miRNA sponge (ceRNA) interacting with hsa-miR-4524a-3p to affect hub genes (e.g., CDC7, CCNB1, CENPU, ASPM, ECT2, NDC80) enriched in DNA replication/cell cycle.
Biological pathway or process:

cell cycle (promotes); DNA replication (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Agarose gel electrophoresis; Bioinformatics Analysis
Clinical significance:

Potential biomarker in tissue and plasma for HCC (up-regulated in both).
Description:

hsa_circ_0089172 is up-regulated in HCC tissue and plasma and was experimentally validated as a circular, RNase R-resistant transcript that can be excreted into hepatoma-cell culture medium. It is proposed to act as a ceRNA by interacting with hsa-miR-4524a-3p to influence cell-cycle/DNA-replication hub genes (e.g., CDC7, CCNB1, CENPU, ASPM, ECT2, NDC80).
Confidence score:

0.6193
Other information
Title:

Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network.

Journal: Cancer cell international
Published: 2021
PubMed ID: 33482819
Study type:

combined biological and clinical study
Data availability: GSE78520; GSE94508; GSE97332; GSE135806; GSE76903; GSE14520; TCGA-LIHC
Code availability: -